Nanoparticle dermal absorption and toxicity: a review of the literature. 2010 5:42–7.Ĭrosera M, Bovenzi M, Maina G, Adami G, Zanette C, Florio C, et al. Design considerations for tumor-targeted nanoparticles. 2008 182:97–101.Ĭhoi HS, Liu W, Liu F, Nasr K, Misra P, Bawendi MG, et al. Transient pulmonary fibrogenic effect induced by intratracheal instillation of ultrafine amorphous silica in A/J mice. In vivo bio-safety evaluations and diagnostic/therapeutic applications of chemically designed mesoporous silica nanoparticles. Dermal penetration of nanoparticles-what we know and what we don’t. Structure of the skin barrier and its modulation by vesicular formulations. 2011 66:463–4.īouwstra JA, Honeywell-Nguyen PL, Gooris GS, Ponec M. Skin penetration of silica microparticles. Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain. 1999 2:1–30.īharali DJ, Klejbor I, Stachowiak EK, Dutta P, Roy I, Kaur N, et al. Cultured keratinocytes in in vitro dermatotoxicological investigation: a review. MCM-41 as a useful vector for rutin topical formulations: synthesis, characterization and testing. 2013a 393:109–18.īerlier G, Gastaldi L, Sapino S, Miletto I, Bottinelli E, Chirio D, et al. Stabilization of quercetin flavonoid in MCM-41 mesoporous silica: positive effect of surface functionalization. 2011 121:2768–80.īerlier G, Gastaldi L, Ugazio E, Miletto I, Iliade P, Sapino S. Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma. 2016, Manuscript in Publishing.īenezra M, Penate-Medina O, Zanzonico PB, Schaer D, Ow H, Burns A, et al. New generation of fluconazole: a review on existing researches and technologies. Esterase activity in excised and reconstructed human skin – biotransformation of prednicarbate and the model dye fluorescein diacetate. 2004 16:1959–66.īätz F, Klipper W, Korting HC, Henkler F, Landsiedel R, Luch A, et al. Silica particles: a novel drug-delivery system. 2013 102:1468–75.īarbe C, Bartlett J, Kong LG, Finnie K, Lin HQ, Larkin M. Mesoporous silicate MCM-41 as a particulate carrier for octylmethoxycinnamate: sunscreen release and photostability. 2014 185C:45–50.Īmbrogi V, Latterini L, Marmottini F, Pagano C, Ricci M. Penetration of normal, damaged and diseased skin – an in vitro study on dendritic core-multishell nanotransporters. 2011 30:175–86.Īlnasif N, Zoschke C, Fleige E, Brodwolf R, Boreham A, Rühl E, et al. Topical absorption and systemic toxicity. Transporting antitumor drug tamoxifen and its metabolites, 4-Hydroxytamoxifen and endoxifen by chitosan nanoparticles. 2013a 117:6403–9.Īgudelo D, Sanyakamdhorn S, Nafisi S, Tajmir-Riahi HA. Encapsulation of milk-lactoglobulin by chitosan nanoparticles. KeywordsĪgudelo D, Nafisi S, Tajmir-Riahi HA. This review surveys the key experiments on SNP-based formulations in the fields of dermatology and cosmetics with the goal of rationalizing data and informing public health concerns related to silica nanoparticles’ toxicity among scientists and manufacturers handling them while highlighting the research gaps in dermal absorption of these compounds. The knowledge of passage of silica nanoparticles through the skin following skin exposure (intentionally or unintentionally) and subsequent effects is limited. Yet there exist concerns that while the properties of silica nanoparticles have enabled numerous industrial and medical applications, their toxicological and environmental safety mandates evaluation. SNPs are candidates for transcutaneous vaccination and transdermal gene therapy, too. SNP may offer a revolutionized treatment of several skin diseases by controlled and sustained release of drugs to the skin, as well as enhanced skin penetration of encapsulated drug ingredients. Recently, they are emerging in the fields of cosmetics and dermal preparations. Silica nanoparticles (SNPs) have received wide attention in several industries and medicine. Nanotechnology is a rapidly expanding area of research involved in developing science-based solutions for innovative therapeutics.
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